1405 - 1454 (49 years)(Notes: You may have to scroll down or right to see chart.)
| John II(Juan), King of Castile | |
| B: | 06 Mar 1405 |
| D: | 20 Jul 1454 |
| Valladolid, Castile and León, Spain | |
| Maria of Aragón, Queen of Castile | |
| B: | 1396 |
| D: | 1445 |
| Isabella I'the Catholic', Queen of Castile and León | |
| B: | 22 Apr 1451 |
| Madrigal de las Altas Torres, Ávila, Castile and León, Spain | |
| D: | 26 Nov 1504 |
| El Castillo de la Mota, Medina del Campo, Valladolid, Castile and León, Spain | |
| Unknown |
| Isabella of Aragon, Queen consort of Portugal and the Algarves, Princess of Asturias | |
| B: | 02 Oct 1470 |
| Duenas, Palencia, Castile and León, Spain | |
| D: | 28 Aug 1498 |
| Zaragoza (Saragosa), Aragón, Spain | |
| Afonso, Prince of Portugal | |
| B: | 18 May 1475 |
| D: | 13 Jul 1491 |
| Miguel (Michael)'da Paz' de Asturias, Prince of Asturias | |
| B: | 23 Aug 1498 |
| Zaragoza (Saragosa), Aragón, Spain | |
| D: | 19 Jul 1500 |
| Granada, Vega de Granada, Andalucia, Spain | |
| Manuel I, King of Portugal and the Algarves | |
| B: | 31 May 1469 |
| Alcochete, Portugal | |
| D: | 13 Dec 1521 |
| Lisbon, Portugal | |
| Juan of Aragon, Prince of Asturias | |
| B: | 28 Jun 1478 |
| Seville (Sevilla), Andalucia, Spain | |
| D: | 04 Oct 1497 |
| Eleanor Habsburg of Austria, Queen consort of Portugal and France, n Archduchess of Austria | |
| B: | 15 Nov 1498 |
| Louvain (now Leuven), Brabant, Flanders, Belgium | |
| D: | Feb 25, 1558) |
| Talavera, Badajoz, Extremadura, Spain | |
| Manuel I, King of Portugal and the Algarves | |
| B: | 31 May 1469 |
| Alcochete, Portugal | |
| D: | 13 Dec 1521 |
| Lisbon, Portugal | |
| Francis I(François) de Valois, d'Angoulême, King of France, Duke of Brittany, Count of Provence | |
| B: | 12 Sep 1494 |
| Cognac, Charente, Poitou-Charentes, France | |
| D: | 31 Mar 1547 |
| Château de Rambouillet, Rambouillet, Yvelines, Île-de-France, France | |
| Charles V( Carlos I of Spain) Habsburg, Holy Roman Emperor, Archduke of Austria, House of Spanish Habsburg | |
| B: | 24 Feb 1500 |
| Ghent (Gent), Oost-Vlaanderen (East Flanders), Belgium | |
| D: | 21 Sep 1558 |
| Monastery of Yuste, Yuste (Cuacos de Yuste), Extremadura, Spain | |
| Isabella of Portugal | |
| B: | 23 Oct 1503 |
| Portugal | |
| D: | 01 May 1539 |
| Fuensalida Palace, Toledo, Castile-La Mancha, Spain | |
| Isabella Habsburg of Austria, Queen consort of Denmark, Sweden, and Norway, Archduchess of Austria | |
| B: | 18 Jul 1501 |
| Brussels, Brabant, Flanders, Belgium | |
| D: | 19 Jan 1526 |
| Ghent (Gent), Oost-Vlaanderen (East Flanders), Belgium | |
| Christian II, King of Denmark, Sweden and Norway, the Wends and the Goths | |
| B: | 01 Jul 1481 |
| Nyborg Slot (Castle), Funen (Fyn), Denmark | |
| D: | 25 Jan 1559 |
| Kalundborg Castle, Kalundborg, Denmark | |
| Ferdinand I Habsburg, Holy Roman Emperor, King of the Romans, King of Bohemia, Hungary, Croatia and Slavonia, Archduke of Austria | |
| B: | 10 Mar 1503 |
| Alcalá de Henares, Madrid, Spain | |
| D: | 25 Jul 1564 |
| Prague (Praha), Bohemia, Czech Republic | |
| Anna of Bohemia and Hungary | |
| B: | 23 Jul 1503 |
| Buda, Budapest, Hungary | |
| D: | 27 Jan 1547 |
| Prague (Praha), Bohemia, Czech Republic | |
| Mary Habsburg of Austria, Queen consort of Hungary, Croatia and Bohemia, Governor of the Habsburg Netherlands | |
| B: | 18 Sep 1505 |
| Brussels, Brabant, Flanders, Belgium | |
| D: | 18 Oct 1558 |
| Cigales, Valladolid, Castile and León, Spain | |
| Louis II Jagiellon, King of Hungary, Croatia and Bohemia | |
| B: | 01 Jul 1506 |
| Buda, Budapest, Hungary | |
| D: | 29 Aug 1526 |
| Mohács, Hungary | |
| Katherina Habsburg of Austria, Queen consort of Portugal | |
| B: | 14 Jan 1507 |
| Torquemada, Palencia, Castile and León, Spain | |
| D: | 12 Feb 1577/78 |
| Lisbon, Portugal | |
| John III'o Piedoso (the Pious)', King of Portugal | |
| B: | 07 Jun 1502 |
| Palace of Alcáçova, Castelo de São Jorge (St. George), Lisbon, Portugal | |
| D: | 11 Jun 1557 |
| Palace of Ribeira, Lisbon, Portugal | |
| Joanna (Juana)'the Mad' of Castile, Queen consort of Castille and León, Princess of Asturias | |
| B: | 06 Nov 1479 |
| Toledo, Castile-La Mancha, Spain | |
| D: | 12 Apr 1555 |
| Tordesillas, Valladolid, Castile and León, Spain | |
| Philip I'the Handsome', First Habsburg King of Castile and Léon, Count of Artois and Flanders, Count Palatine of Burgundy | |
| B: | 22 Jul 1478 |
| Bruges, Flanders, Belgium | |
| D: | 25 Sep 1506 |
| Burgos, Castile and León, Spain | |
| Maria of Aragon, Queen consort of Portugal, Princess of Asturias | |
| B: | 29 Jun 1482 |
| D: | 07 Mar 1517 |
| Manuel I, King of Portugal and the Algarves | |
| B: | 31 May 1469 |
| Alcochete, Portugal | |
| D: | 13 Dec 1521 |
| Lisbon, Portugal | |
| Catherine of Aragon, Queen consort of England, Princess of Asturias | |
| B: | 16 Dec 1485 |
| Laredo Palace, Alcalá de Henares, Madrid, Spain | |
| D: | 07 Jan 1536 |
| Kimbolton Castle, Kimbolton, Huntingdonshire, England | |
| Arthur Tudor, Prince of Wales | |
| B: | 20 Sep 1486 |
| Winchester, Hampshire, England | |
| D: | 02 Apr 1502 |
| Ludlow Castle, Ludlow, Shropshire, England | |
| Henry Tudor, Duke of Cornwall | |
| B: | Dec 1514 |
| England | |
| D: | Abt Jan 1514 |
| Stillborn daughter | |
| B: | 31 Jan 1510 |
| D: | 31 Jan 1510 |
| Henry, Duke of Cornwall | |
| B: | 1 Jan 1511 |
| D: | 23 Feb 1511 |
| 'Bloody' Mary I Tudor, Queen of England and Ireland, Queen consort of Spain | |
| B: | 18 Feb 1516 |
| Palace of Placentia, Greenwich, Kent, England | |
| D: | 17 Nov 1558 |
| St. James' Palace, Pall Mall, Westminster, Middlesex, England | |
| Philip II, King of Spain, King of England and Ireland Jure uxoris (by right of his wife), King of Portugal and the Algarves, House of Spanish Habsburg | |
| B: | 21 May 1527 |
| Valladolid, Castile and León, Spain | |
| D: | 13 Sep 1598 |
| Madrid, Spain | |
| Stillborn son | |
| B: | Oct 1513 |
| D: | Oct 1513 |
| Henry, Duke of Cornwall | |
| B: | Dec 1514 |
| D: | Dec 1514 |
| Unnamed daughter | |
| B: | 10 Nov 1518 |
| D: | Nov 1518 |
| Henry VIII Tudor, King of England and Ireland | |
| B: | 28 Jun 1491 |
| Greenwich Palace, Greenwich, Kent, England | |
| D: | 28 Jan 1547 |
| Palace of Whitehall, Whitehall, Westminster, Middlesex, England | |
| Ferdinand II'the Catholic', King of Aragón | |
| B: | 10 Mar 1452 |
| Spain | |
| D: | 23 Jan 1516 |
| Alfonso, Prince of Asturias | |
| B: | 1453 |
| D: | 1468 |
| Isabella of Portugal, Queen consort of Castile and Leon | |
| B: | 1428 |
| D: | 15 Aug 1496 |
